The Fourth Industrial Revolution (Industry 4.0) is imminent in the South African economy. Industry 4.0 is disruptive and challenges the status quo. This paper investigates the preparedness of South Africa for Industry 4.0 implementation. Government policies and initiatives on innovation and manufacturing are reviewed and presented to determine their position relative to Industry 4.0. Key statistics on education, skills and employment are presented and analysed to assess how well prepared the education system is to supply skills required in Industry 4.0. Based on the analysis and reviews of policy and key data recommendations are presented which highlight important actions to ensure optimal Industry 4.0 implementation.